EP300 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A13016-20, A13016-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Category: Polyclonal Antibodies
Applications: IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 264kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 2033
SWISS: Q09472
Alternate Names: p300; KAT3B; MKHK2; RSTS2; EP300
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Transcription Factors, Nuclear Receptor Signaling, Cancer, Tumor suppressors, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cell Cycle Control-G2 M DNA Damage Checkpoint, Endocrine Metabolism, Mitochondrial metabolism, Endocrine and metabolic diseases, Obesity, Immunology Inflammation, NF-kB Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Stem Cells, Cardiovascular, Angiogenesis.
NCBI Alias: EP300
Research Use Only