EPHA3/EPHA4/EPHA5 pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A20254-20, A20254-100
Citations, Manuals and MSDS Available upon request.
Background: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Category: Polyclonal Antibodies
Applications: IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Observed Molecular Weight: Refer to figures
Immunogen: Synthetic peptide
Species: Human
GeneID: 2042/2043/2044
SWISS: P29320/P54764/P54756
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Protein phosphorylation, Signal Transduction, Kinase, Tyrosine kinases, Neuroscience, Cell Type Marker, Cardiovascular, Angiogenesis, Neuron marker.
NCBI Alias: EPHA3/EPHA4/EPHA5
Research Use Only