EWSR1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A13978-20, A13978-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11;22) (q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Category: Polyclonal Antibodies
Applications: IF/ICC, ELISA
Cross-reactivity: Human
Protein Weight: 68kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 2130
SWISS: Q01844
Alternate Names: EWS; EWS-FLI1; bK984G1.4; EWSR1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: IF/ICC, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, RNA Binding, Cancer.
NCBI Alias: EWSR1
Research Use Only