FLT3 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A12437-20, A12437-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 113kDa
Observed Molecular Weight: 130kDa/160kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 2322
SWISS: P36888
Alternate Names: FLK2; STK1; CD135; FLK-2; FLT3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:100 - 1:500 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Protein phosphorylation, Signal Transduction, Kinase, Tyrosine kinases, Immunology Inflammation, CDs, Stem Cells.
NCBI Alias: FLT3
Research Use Only