GABA transaminase (ABAT) Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A5299-20, A5299-100
Citations, Manuals and MSDS Available upon request.
Background: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, IF-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 56kDa
Observed Molecular Weight: 50kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 18
SWISS: P80404
Alternate Names: GABAT; NPD009; GABA-AT; GABA transaminase (ABAT)
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Mitochondrial metabolism, Mitochondrial markers, Amino acid metabolism, Neuroscience, Neurodegenerative Diseases Markers, Other Neurological disorders.
NCBI Alias: ABAT
Research Use Only