HDAC5 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A7189-20, A7189-100
Citations, Manuals and MSDS Available upon request.
Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human
Protein Weight: 122kDa
Observed Molecular Weight: 121kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 10014
SWISS: Q9UQL6
Alternate Names: HD5; NY-CO-9; HDAC5
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:20 - 1:50 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Nuclear Receptor Signaling, Protein phosphorylation, Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Cell Cycle Control-G1 S Checkpoint, Wnt -Catenin Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway, Stem Cells, Cardiovascular, Heart, Hypertrophy.
NCBI Alias: HDAC5
Research Use Only