HP1 alpha/CBX5 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1098-20, A1098-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, IP, ELISA, ChIP
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 22kDa
Observed Molecular Weight: 22kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 23468
SWISS: P45973
Alternate Names: HP1; HP1A; HEL25; HP1 alpha/CBX5
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. ChIP, 1:20 - 1:100
Research Areas: Epigenetics Nuclear Signaling.
NCBI Alias: CBX5
Research Use Only