IBTK Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14866-20, A14866-100
Citations, Manuals and MSDS Available upon request.
Background: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human
Protein Weight: 151kDa
Observed Molecular Weight: 150kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 25998
SWISS: Q9P2D0
Alternate Names: BTKI; BTBD26; IBTK
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Kinase.
NCBI Alias: IBTK
Research Use Only