IL15 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A24510-20, A24510-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x (L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse
Protein Weight: 14kDa/18kDa
Observed Molecular Weight: 18kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 3600
SWISS: P40933
Alternate Names: IL15; IL-15; interleukin-15
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Tumor immunology, Endocrine & Metabolism, Endocrine and metabolic diseases, Obesity, Immunology & Inflammation, Cytokines, Interleukins, Cell Intrinsic Innate Immunity Signaling Pathway.
NCBI Alias: IL15
Research Use Only