Insulin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2090-20, A2090-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
Category: Polyclonal Antibodies
Applications: WB, IF-P, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 12kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 3630
SWISS: P01308
Alternate Names: IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10; Insulin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF-P, 1:50 - 1:200 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Cell Biology Developmental Biology, Growth factors, Endocrine Metabolism, AMPK Signaling Pathway, Endocrine and metabolic diseases, Diabetes, Obesity, Immunology Inflammation, NF-kB Signaling Pathway, Neuroscience, Stem Cells, Cardiovascular, Heart, Cardiovascular diseases, Heart disease.
NCBI Alias: INS
Research Use Only