Insulin Receptor Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A16900-20, A16900-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IP, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 156kDa
Observed Molecular Weight: 110kDa/220kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 3643
SWISS: P06213
Alternate Names: HHF5; CD220; Insulin Receptor
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Growth factors, Endocrine Metabolism, AMPK Signaling Pathway, Insulin Receptor Signaling Pathway, Endocrine and metabolic diseases, Diabetes, Immunology Inflammation, CDs, Neuroscience, Cardiovascular, Heart, Cardiovascular diseases, Heart disease.
NCBI Alias: INSR
Research Use Only