IRF3 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A11118-20, A11118-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, IP, ELISA, ChIP
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 47kDa
Observed Molecular Weight: 47kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 3661
SWISS: Q14653
Alternate Names: IIAE7; IRF3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. ChIP, 5μg antibody for 10μg-15μg of Chromatin
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Immunology Inflammation, Cytokines, Toll-like Receptor Signaling Pathway, Cell Intrinsic Innate Immunity Signaling Pathway, TLR Signaling.
NCBI Alias: IRF3
Research Use Only