IRS1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A28406-20, A28406-100
Citations, Manuals and MSDS Available upon request.
Background: Enables phosphatidylinositol 3-kinase activator activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in cellular response to fatty acid; insulin receptor signaling pathway; and insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of epithelial cell migration; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog (s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1) .
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse
Protein Weight: 131 kDa
Observed Molecular Weight: 180 kDa
Immunogen: Synthetic peptide .
Species: Mouse
GeneID: 16367
SWISS: P35569
Alternate Names: G972R; IRS-1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. For high-ratio antibody dilutions (≥1:10000) ，a sequential dilution method is strongly recommended to ensure measurement accuracy.
Research Areas: Metabolism
NCBI Alias: Irs1
Research Use Only