JAM-A/CD321/F11R Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1241-20, A1241-100
Citations, Manuals and MSDS Available upon request.
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 33kDa
Observed Molecular Weight: 37kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 50848
SWISS: Q9Y624
Alternate Names: JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; JAM-A/CD321/F11R
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Tight Junctions, Cytoskeleton, Immunology Inflammation, CDs, Cardiovascular, Blood.
NCBI Alias: F11R
Research Use Only