[KD Validated]FGFR3 Rabbit pAb - A24846

[KD Validated]FGFR3 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A24846-20, A24846-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Category: Polyclonal Antibodies

Applications: WB, FC, ELISA

Cross-reactivity: Human

Protein Weight: 75kDa/85kDa/87kDa/88kDa

Observed Molecular Weight: 100-150kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 2261

SWISS: P22607

Alternate Names: FGFR3; ACH; CD333; CEK2; HSFGFR3EX; JTK4; fibroblast growth factor receptor 3

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology & Developmental Biology, Growth factor, ESC Pluripotency and Differentiation, Immunology & Inflammation, CD markers, Stem Cells, Neural Stem Cells, Cardiovascular, Angiogenesis.

NCBI Alias: FGFR3

Research Use Only