[KO Validated] BRG1/SMARCA4 Rabbit pAb - A2117

[KO Validated] BRG1/SMARCA4 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A2117-20, A2117-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, IF/ICC, IP, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 185kDa

Observed Molecular Weight: 220kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 6597

SWISS: P51532

Alternate Names: BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta; A4

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azide, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Chromatin Remodeling, Cancer, Tumor suppressors, Neuroscience, Cell Type Marker, Stem Cells.

NCBI Alias: SMARCA4

Research Use Only