[KO Validated] CDK8 Rabbit pAb - A5548

[KO Validated] CDK8 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A5548-20, A5548-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IP, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 53kDa

Observed Molecular Weight: 56kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 1024

SWISS: P49336

Alternate Names: K35; IDDHBA; K8

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Signal Transduction, Kinase, Serine threonine kinases, Cell Biology Developmental Biology, Cell Cycle, Wnt -Catenin Signaling Pathway.

NCBI Alias: CDK8

Research Use Only