[KO Validated] CHCHD2 Rabbit pAb - A16645

[KO Validated] CHCHD2 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A16645-20, A16645-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to a class of eukaryotic CX (9) C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, IF/ICC, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 16kDa

Observed Molecular Weight: 16kDa

Immunogen: Recombinant protein (or fragment)

Species: Human

GeneID: 51142

SWISS: Q9Y6H1

Alternate Names: MNRR1; NS2TP; MIX17B; PARK22; C7orf17; D2

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cell Biology Developmental Biology.

NCBI Alias: CHCHD2

Research Use Only