[KO Validated] PRMT6 Rabbit pAb - A7814

[KO Validated] PRMT6 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A7814-20, A7814-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.

Category: Polyclonal Antibodies

Applications: WB, IF/ICC, ELISA

Cross-reactivity: Human, Mouse

Protein Weight: 42kDa

Observed Molecular Weight: 42kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 55170

SWISS: Q96LA8

Alternate Names: HRMT1L6; T6

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones.

NCBI Alias: PRMT6

Research Use Only