[KO Validated] PTPN1 Rabbit pAb - A22243

[KO Validated] PTPN1 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A22243-20, A22243-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Category: Polyclonal Antibodies

Applications: WB, ELISA

Cross-reactivity: Human, Rat

Protein Weight: 50kDa

Observed Molecular Weight: 50kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 5770

SWISS: P18031

Alternate Names: PTP1B; N1

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Cell Adhesion, Endocrine Metabolism, Insulin Receptor Signaling Pathway, Endocrine and metabolic diseases, Diabetes, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Cardiovascular.

NCBI Alias: PTPN1

Research Use Only