[KO Validated] Rap1A Rabbit pAb - A0975

[KO Validated] Rap1A Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A0975-20, A0975-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 21kDa

Observed Molecular Weight: 21kDa

Immunogen: Synthetic peptide

Species: Human

GeneID: 5906

SWISS: P62834

Alternate Names: RAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21; 1A

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Signal Transduction, G protein signaling, Small G proteins, G-Protein-Coupled Receptors Signaling to MAPK Erk, MAPK-Erk Signaling Pathway, Immunology Inflammation, B Cell Receptor Signaling Pathway.

NCBI Alias: RAP1A

Research Use Only