[KO Validated] STRADA Rabbit pAb - A18012

[KO Validated] STRADA Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A18012-20, A18012-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25) . The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.

Category: Polyclonal Antibodies

Applications: WB, ELISA

Cross-reactivity: Human, Mouse

Protein Weight: 48kDa

Observed Molecular Weight: 48kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 92335

SWISS: Q7RTN6

Alternate Names: LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha; DA

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:1000 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cancer, Tumor immunology, Tumor-associated antigens, Tumor biomarkers, Kinase, Cell Biology Developmental Biology, Cell Cycle, Cell cycle inhibitors, Endocrine Metabolism, AMPK Signaling Pathway, Immunology Inflammation.

NCBI Alias: STRADA

Research Use Only