Lamin A/C Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A0249-20, A0249-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA, ChIP
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 74kDa
Observed Molecular Weight: 68kDa/72kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 4000
SWISS: P02545
Alternate Names: FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B; Lamin A/C
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. ChIP, 1:20 - 1:100
Research Areas: Protein phosphorylation, Signal Transduction, PI3K-Akt Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cytoskeleton, Intermediate Filaments, Death Receptor Signaling Pathway, Stem Cells.
NCBI Alias: LMNA
Research Use Only