Langerin/CD207 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A25467-20, A25467-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
Category: Polyclonal Antibodies
Applications: IHC-P, ELISA
Cross-reactivity: Human
Protein Weight: 37 kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 50489
SWISS: Q9UJ71
Alternate Names: CLEC4K; Langerin/CD207
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: IHC-P, 1:500- 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Immunology Inflammation, CDs.
NCBI Alias: CD207
Research Use Only