Leptin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A5673-20, A5673-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development.
Category: Polyclonal Antibodies
Applications: IHC-P, ELISA
Cross-reactivity: Human
Protein Weight: 19kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 3952
SWISS: P41159
Alternate Names: OB; OBS; LEPD; Leptin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Cell Biology Developmental Biology, Growth factors, Endocrine Metabolism, Endocrine and metabolic diseases, Diabetes, Obesity, Neuroscience, Stem Cells, Mesenchymal Stem Cells, Cardiovascular, Heart, Cardiovascular diseases, Heart disease.
NCBI Alias: LEP
Research Use Only