Leptin Receptor Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2999-20, A2999-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021) .
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Rat
Protein Weight: 132kDa
Observed Molecular Weight: 140kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 3953
SWISS: P48357
Alternate Names: OBR; OB-R; CD295; LEP-R; LEPRD; Leptin Receptor
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Cell Biology Developmental Biology, Growth factors, Endocrine Metabolism, Lipid Metabolism, AMPK Signaling Pathway, Endocrine and metabolic diseases, Obesity, Immunology Inflammation, CDs, Cardiovascular, Lipids, Fatty Acids.
NCBI Alias: LEPR
Research Use Only