Mineralocorticoid receptor (NR3C2) Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A3308-20, A3308-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 107kDa
Observed Molecular Weight: 100kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 4306
SWISS: P08235
Alternate Names: MR; MCR; MLR; NR3C2VIT; Mineralocorticoid receptor (NR3C2)
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Nuclear Receptor Signaling, Nuclear hormone receptors, Signal Transduction, Cardiovascular, Heart, Hypertrophy, Cardiovascular diseases.
NCBI Alias: NR3C2
Research Use Only