NOTCH3 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A13522-20, A13522-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 244kDa
Observed Molecular Weight: 90kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 4854
SWISS: Q9UM47
Alternate Names: IMF2; LMNS; CASIL; CADASIL; CADASIL1; NOTCH3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Cell differentiation, ESC Pluripotency and Differentiation, Neuroscience, Stem Cells, Hematopoietic Progenitors, Neural Stem Cells, Cardiovascular, Heart, Cardiogenesis.
NCBI Alias: NOTCH3
Research Use Only