PANK2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A18502-20, A18502-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse
Protein Weight: 63kDa
Observed Molecular Weight: 63kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 80025
SWISS: Q9BZ23
Alternate Names: HSS; HARP; PKAN; NBIA1; C20orf48; PANK2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Endocrine Metabolism, Neuroscience, Neurodegenerative Diseases.
NCBI Alias: PANK2
Research Use Only