PARP1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A0942-20, A0942-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 113kDa
Observed Molecular Weight: 89kDa/113kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 142
SWISS: P09874
Alternate Names: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP; PARP1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, DNA Damage Repair, RNA Binding, Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Centrosome, Death Receptor Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway.
NCBI Alias: PARP1
Research Use Only