PCSK9 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A24478-20, A24478-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, IP, ELISA
Cross-reactivity: Human, Rat
Protein Weight: 20kDa/74kDa
Observed Molecular Weight: 65kDa/80kDa/65kDa, 80kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 255738
SWISS: Q8NBP7
Alternate Names: PCSK9; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; proprotein convertase subtilisin/kexin type 9
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics & Nuclear Signaling, RNA Binding, Cancer, Signal Transduction, Cell Biology & Developmental Biology, Apoptosis, Ubiquitin, Endocrine & Metabolism, Amino acid metabolism, Lipid Metabolism, Cholesterol Metabolism, Stem Cells, Neural Stem Cells, Cardiovascular, Lipids.
NCBI Alias: PCSK9
Research Use Only