PIM1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A24475-20, A24475-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810) .
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 35kDa/45kDa
Observed Molecular Weight: 44kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 5292
SWISS: P11309
Alternate Names: PIM1; PIM; serine/threonine-protein kinase pim-1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics & Nuclear Signaling, Chromatin Modifying Enzymes, Phosphorylation, Chromatin Remodeling, Cancer, Signal Transduction, Kinase, Serine/threonine kinases, Cell Biology & Developmental Biology, Apoptosis, Immunology & Inflammation, IL-6 Receptor Signaling Pathway, Stem Cells, Hematopoietic Progenitors.
NCBI Alias: PIM1
Research Use Only