PPM1F Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A15363-20, A15363-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human
Protein Weight: 50kDa
Observed Molecular Weight: 55kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 9647
SWISS: P49593
Alternate Names: CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase; PPM1F
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Kinase, Cell Biology Developmental Biology, Apoptosis, Neuroscience, Calcium Signaling.
NCBI Alias: PPM1F
Research Use Only