Recombinant Human Calmodulin-1/CALM1 Protein
Sizes: 10ug, 50ug
Catalogue Number: RP02931-10, RP02931-50
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human Calmodulin-1/CALM1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Lys149) of human Calmodulin-1/CALM1 (Accession #NP_001316851.1) fused with no additional amino acid.
Alternate Names: CALM1, CALML2, CAMI, CPVT4, DD132, LQT14, PHKD, caM, CAMI, CPVT4, DD132, LQT14, PHKD, caM
SWISS: P0DP23
GeneID: 801/805/808
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of Calmodulin. Once bound to Ca2+, Calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases. Calmodulin is a small, highly conserved protein that is 148 amino acids long. The protein has two approximately symmetrical globular domains each containing a pair of EF-hand motifs (the N- and C-domain) separated by a flexible linker region for a total of four Ca2+ binding sites. Calmodulin mediates many crucial processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, and the immune response. Calmodulin is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes, but it is always found intracellularly.
Source: E. coli
Tag: No tag
Formulation: Lyophilized from a 0.22 μm filtered solution of 50mM NH4HCO3, pH 8.0.
Antigen Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Endotoxin: < 1 EU/μg of the protein by LAL method.
Research Use Only