Recombinant Human DDR2/CD167b Protein
Sizes: 20ug, 50ug, 100ug
Catalogue Numbers: RP00115-20, RP00115-50, RP00115-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human DDR2/CD167b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Arg399) of human DDR2 Kinase/CD167b Kinase/CD167b (Accession #NP_001014796.1) fused with a 6×His tag at the C-terminus.
Alternate Names: DDR2, MIG20a, NTRKR3, TKT, TYRO10, NTRKR3, TKT, TYRO10
SWISS: Q16832
GeneID: 4921
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Bio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DDR2 Protein at 1 μg/mL (100 μL/well) can bind DDR2 Rabbit mAb with a linear range of 0.486-33.97 ng/mL.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: QVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTR
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only