Recombinant Human Fc-gamma RIII alpha/CD16a(F176V) Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01366-10, RP01366-20, RP01366-50, RP01366-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human Fc-gamma RIII alpha/CD16a(F176V) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly17-Gln208(F176V)) of human FCGR3A/CD16A(F176V) (Accession #NP_001121065.1) fused with a 6×His tag at the C-terminus.
Alternate Names: CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, FCGR3A
SWISS: P08637
GeneID: 2214 (F176V)
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: This protein is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. The protein is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFFPPGYQ
Endotoxin: < 1 EU/μg of the protein by LAL method.
Research Use Only