Recombinant Human GFER/ALR Protein
Sizes: 10ug, 50ug
Catalogue Number: RP02175-10, RP02175-50
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human GFER/ALR Protein is produced by E.coli expression system. The target protein is expressed with sequence (Met1-Asp125) of human GFER (Accession #P55789) fused with a 6xHis tag at the N-terminus.
Alternate Names: GFER, ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS
SWISS: P55789
GeneID: 2671
Species: Human
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S- adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
Source: E. coli
Tag: N-His
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Endotoxin: < 1 EU/μg of the protein by LAL method.
Research Use Only