Recombinant Human IL-1 Rrp2/IL-1 R6 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01547-10, RP01547-20, RP01547-50, RP01547-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human IL-1 Rrp2/IL-1 R6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp20-Arg335) of human IL-1 Rrp2/IL-1 R6 (Accession #NP_003845.2) fused with a hFc tag at the C-terminus.
Alternate Names: IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, IL36R
SWISS: Q9HB29
GeneID: 8808
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: IL1RL2 (Interleukin 1 Receptor-Like 2, also known as IL-36R) is a Protein Coding gene. The protein encoded by this gene is a member of the interleukin 1 receptor family. This gene and four other interleukin 1 receptor family genes form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. The IL36 receptor is an important mediator molecule in the inflammatory response. Animal data suggest that IL1RL2 is involved in mucosal healing. Therapeutic intervention of IL-36R signaling offers an innovative treatment paradigm for targeting epithelial cell-mediated inflammatory diseases such as the life-threatening psoriasis variant called generalized pustular psoriasis (GPP). Diseases associated with IL1RL2 include Familial Cold Autoinflammatory Syndrome 2 and Geographic Tongue.
Bio-Activity: Measured by its binding ability in a functional ELISA. Immobilized human IL-36 beta (Catalog: RP00020) at 10 μg/mL (100 μL/well) can bind human IL1RL2(Catalog: RP01547) with a linear range of 0.018-2.62 μg/mL.
Source: HEK293 cells
Tag: C-hFc
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: DGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFR
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only