Recombinant Human IL-17RA/CD217 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP00273-10, RP00273-20, RP00273-50, RP00273-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human IL-17RA/CD217 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu33-Trp320) of human IL17RA (Accession #NP_055154.3) fused with a 6×His tag at the C-terminus.
Alternate Names: CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, IL17RA, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R
SWISS: Q96F46
GeneID: 23765
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. This transmembrane protein (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.
Bio-Activity: 1.Measured by its ability to inhibit IL-17A induced IL-6 secretion by Hela cells. The ED50 for this effect is 0.02 0.1 μg/mL in the presence of 10 ng/mL recombinant human IL 17A.|2.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA , His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A,His Tag with a linear range of 31.25-65 ng/mL.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only