Recombinant Human IL-1R2/CD121b Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01028-10, RP01028-20, RP01028-50, RP01028-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human IL-1R2/CD121b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu343) of human IL1R2 (Accession #NP_004624.1) fused with a 6×His tag at the C-terminus.
Alternate Names: IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB
SWISS: P27930
GeneID: 7850
Species: Human
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Bio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1R2 at 2 μg/mL (100 μL/well) can bind Human IL1RA with a linear range of 31.25-43.5 ng/mL.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKE
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only