Recombinant Human LAIR-2/CD306 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01034-10, RP01034-20, RP01034-50, RP01034-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human LAIR-2/CD306 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Pro152) of human LAIR2 (Accession #NP_002279) fused with a 6×His tag at the C-terminus.
Alternate Names: LAIR2, CD306
SWISS: Q6ISS4
GeneID: 3904
Species: Human
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD36, is a 131 amino acid protein containing one lg-like C2-type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% aa identity across the signal sequence and extracellular domains, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. LAIR2 is thought to be secreted and may help modulate mucosal tolerance.
Bio-Activity: Measured by the ability of the immobilized protein to support the adhesion of HT-29 human colon adenocarcinoma cells. When 5 x 104 cells/well are added to rhLAIR-2 coated plates (50 μg/mL with 100 μL/well), approximately 50%-60% will adhere after 10 minutes at 37℃.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Antigen Sequence: QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAP
Endotoxin: < 0.1 EU/μg of the protein by LAL method.
Research Use Only