Recombinant Human MMP-8 Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP02626-10, RP02626-20, RP02626-50, RP02626-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human MMP-8 Protein is expressed from Expi293 with His tag at the C-terminal.; It contains Phe21-Gly467.
Alternate Names: MMP-8; PMNL-CL; CLG1; MMP8; Collagenase 2; PMNL-CL; HNC
SWISS: P22894
GeneID: 4317
Species: Human
Purity: ≥ 95 % as determined by Tris-Bis PAGE; ≥ 95 % as determined by HPLC.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was significantly associated with low HCS.
Bio-Activity: Recombinant Human MMP-8 Protein cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (RD,Catalog # ES001). The specific activity is >194 pmol/min/µg, as measured under the described conditions.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.2 μm filtered solution of 50mM Tris , 10 mM CaCl2, 150 mM NaCl, pH 7.5. Contact us for customized product form or formulation.
Antigen Sequence: FPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Endotoxin: < 0.01 EU/μg of the protein by LAL method
Research Use Only