Recombinant Human/Mouse/Rat mature Activin A/INHBA Protein
Sizes: 10ug, 20g, 50ug, 100ug
Catalogue Numbers: RP01782S-10, RP01782S-20, RP01782S-50, RP01782S-100
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Human/Mouse/Rat mature Activin A/INHBA Protein is produced by CHO cells expression system. The target protein is expressed with sequence (Gly311-Ser426) of Human/Mouse/Rat mature Activin A/INHBA (Accession #NP_002183.1) fused with No Tag.
Alternate Names: EDF; FRP; INHBA; Activin A
SWISS: P08476
GeneID: 3624
Species: Human,Mouse,Rat
Purity: ≥ 90 % as determined by SDS-PAGE.
Storage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Bio-Activity: Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 3.215-12.86 ng/mL, corresponding to a specific activity of 7.78×10^4 ~3.11×10^5 units/mg.
Source: CHO Cells
Tag: No-Tag
Formulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Antigen Sequence: GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Endotoxin: < 0.01 EU/μg of the protein by LAL method
Research Use Only