Recombinant Mouse Fc gamma RI/FCGR1/CD64 Protein
Sizes: 10ug, 50ug
Catalogue Number: RP00710-10, RP00710-50
Citations, Manuals and MSDS Available upon request.
Description: Recombinant Mouse Fc gamma RI/FCGR1/CD64 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Glu25-Pro297) of mouse Fc γ RI/FCGR1A/CD64 (Accession #P26151) fused with a 6×His tag at the C-terminus.
Alternate Names: High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, CD64, Fcgr1
SWISS: P26151
GeneID: 14129
Species: Mouse
Purity: ≥ 95 % as determined by SDS-PAGE.
Storage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
Background: CD64, also known as Fc-gamma receptor 1 (Fc γ RI), is a type of integral membrane glycoprotein that bindsmonomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chainknown as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellularactivation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-typeused to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediatesendocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxideproduction. It is normally expressed on the surfaces of monocytes and macrophages.
Source: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. Contact us for customized product form or formulation.
Antigen Sequence: EVVNATKAVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFSSDSEVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSPFPEGSLVTLNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDSSVL
Endotoxin: < 1 EU/μg of the protein by LAL method.
Research Use Only