RNASEH2A Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A15132-20, A15132-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Rat
Protein Weight: 33kDa
Observed Molecular Weight: 33kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 10535
SWISS: O75792
Alternate Names: AGS4; JUNB; RNHL; RNHIA; THSD8; RNASEHI; RNASEH2A
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling.
NCBI Alias: RNASEH2A
Research Use Only