SERCA2/ATP2A2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A1097-20, A1097-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 115kDa
Observed Molecular Weight: 115kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 488
SWISS: P16615
Alternate Names: DD; DAR; ATP2B; SERCA2; SERCA2/ATP2A2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:2000 - 1:10000 IHC-P, 1:50 - 1:200 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Neuroscience, Calcium Signaling, Neurodegenerative Diseases, Cardiovascular, Heart, Contractility.
NCBI Alias: ATP2A2
Research Use Only