SLC12A1 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A12999-20, A12999-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 121kDa
Observed Molecular Weight: 150kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 6557
SWISS: Q13621
Alternate Names: BSC; BSC1; CCC2; BSC-1; NKCC2; SLC12A1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
NCBI Alias: SLC12A1
Research Use Only