SOCS2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A17035-20, A17035-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN) -gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human
Protein Weight: 22kDa
Observed Molecular Weight: 22kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 8835
SWISS: O14508
Alternate Names: CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2; SOCS2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, Cytokines, Jak-Stat-IL-6 Receptor Signaling Pathway, Cell Intrinsic Innate Immunity Signaling Pathway, Neuroscience.
NCBI Alias: SOCS2
Research Use Only