TNFRSF25 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14261-20, A14261-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Category: Polyclonal Antibodies
Applications: WB, IF-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 45kDa
Observed Molecular Weight: 60kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 8718
SWISS: Q93038
Alternate Names: DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12; TNFRSF25
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IF-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Death Receptor Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway.
NCBI Alias: TNFRSF25
Research Use Only