TTK Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2500-20, A2500-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 97kDa
Observed Molecular Weight: 100kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 7272
SWISS: P33981
Alternate Names: ESK; PYT; CT96; MPH1; MPS1; MPS1L1; TTK
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:5000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Signal Transduction, Kinase, Cell Biology Developmental Biology, Apoptosis, Cell Cycle.
NCBI Alias: TTK
Research Use Only